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Apparent diffusion coefficient ratio correlates significantly with prostate cancer gleason score at final pathology
Author(s) -
Boesen Lars,
Chabanova Elizaveta,
Løgager Vibeke,
Balslev Ingegerd,
Thomsen Henrik S.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24801
Subject(s) - prostatectomy , medicine , effective diffusion coefficient , prostate cancer , receiver operating characteristic , spearman's rank correlation coefficient , magnetic resonance imaging , prostate , correlation , diffusion mri , urology , area under the curve , nuclear medicine , radiology , cancer , mathematics , statistics , geometry
Purpose To evaluate the correlation between apparent diffusion coefficient measurements (ADC tumor and ADC ratio ) and the Gleason score from radical prostatectomy specimens. Materials and Methods Seventy‐one patients with clinically localized prostate cancer scheduled for radical prostatectomy were prospectively enrolled. Multiparametric magnetic resonance imaging (MRI) was performed prior to prostatectomy and mean ADC values from both cancerous (ADC tumor ) and benign (ADC benign ) tissue were measured to calculate the ADC ratio (ADC tumor divided by ADC benign ). The ADC measurements were correlated with the Gleason score from the prostatectomy specimens. Results The association between ADC measurements and Gleason score showed a significant negative correlation ( P < 0.001) with Spearman's rho for ADC tumor (−0.421) and ADC ratio (−0.649). There was a statistically significant difference between ADC measurements and the Gleason score for all tumors ( P = 0.001). Receiver operating characteristic curve analysis showed an overall area under the curve (AUC) of 0.73 (ADC tumor ) to 0.80 (ADC ratio ) in discriminating Gleason score 6 from Gleason score ≥7 tumors. The AUC changed to 0.72 (ADC tumor ) and 0.90 (ADC ratio ) when discriminating Gleason score ≤7(3+4) from Gleason score ≥7(4+3). Conclusion ADC measurements showed a significant correlation with tumor Gleason score at final pathology. The ADC ratio demonstrated the best correlation compared to the ADC tumor value and radically improved accuracy in discriminating Gleason score ≤7(3+4) from Gleason score ≥7(4+3) tumors. J. Magn. Reson. Imaging 2014. J. Magn. Reson. Imaging 2015;42:446–453.