Premium
3D ECG‐ and respiratory‐gated non‐contrast‐enhanced (CE) perfusion MRI for postoperative lung function prediction in non‐small‐cell lung cancer patients: A comparison with thin‐section quantitative computed tomography, dynamic CE‐perfusion MRI, and perfusion scan
Author(s) -
Ohno Yoshiharu,
Seki Shinichiro,
Koyama Hisanobu,
Yoshikawa Takeshi,
Matsumoto Sumiaki,
Takenaka Daisuke,
Kassai Yoshimori,
Yui Masao,
Sugimura Kazuro
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24800
Subject(s) - perfusion , medicine , perfusion scanning , nuclear medicine , lung , dynamic contrast , lung cancer , dynamic contrast enhanced mri , radiology , lung volumes , tomography , magnetic resonance imaging
Purpose To compare predictive capabilities of non‐contrast‐enhanced (CE)‐ and dynamic CE‐perfusion MRIs, thin‐section multidetector computed tomography (CT) (MDCT), and perfusion scan for postoperative lung function in non‐small cell lung cancer (NSCLC) patients. Materials and Methods Sixty consecutive pathologically diagnosed NSCLC patients were included and prospectively underwent thin‐section MDCT, non‐CE‐, and dynamic CE‐perfusion MRIs and perfusion scan, and had their pre‐ and postoperative forced expiratory volume in one second (FEV 1 ) measured. Postoperative percent FEV 1 (po%FEV 1 ) was then predicted from the fractional lung volume determined on semiquantitatively assessed non‐CE‐ and dynamic CE‐perfusion MRIs, from the functional lung volumes determined on quantitative CT, from the number of segments observed on qualitative CT, and from uptakes detected on perfusion scans within total and resected lungs. Predicted po%FEV 1 s were then correlated with actual po%FEV 1 s, which were %FEV 1 s measured postoperatively. The limits of agreement were also determined. Results All predicted po%FEV 1 s showed significant correlation (0.73 ≤ r ≤ 0.93, P < 0.0001) and limits of agreement with actual po%FEV 1 (non‐CE‐perfusion MRI: 0.3 ± 10.0%, dynamic CE‐perfusion MRI: 1.0 ± 10.8%, perfusion scan: 2.2 ± 14.1%, quantitative CT: 1.2 ± 9.0%, qualitative CT: 1.5 ± 10.2%). Conclusion Non‐CE‐perfusion MRI may be able to predict postoperative lung function more accurately than qualitatively assessed MDCT and perfusion scan. J. Magn. Reson. Imaging 2015;42:340–353.