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Association of overall survival in patients with newly diagnosed glioblastoma with contrast‐enhanced perfusion MRI: Comparison of intraindividually matched T 1 ‐ and T 2 * ‐based bolus techniques
Author(s) -
Bonekamp David,
Deike Katerina,
Wiestler Benedikt,
Wick Wolfgang,
Bendszus Martin,
Radbruch Alexander,
Heiland Sabine
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24756
Subject(s) - medicine , glioblastoma , nuclear medicine , perfusion , cerebral blood volume , receiver operating characteristic , bolus (digestion) , dynamic contrast , area under the curve , magnetic resonance imaging , radiology , cancer research
Background To compare intraindividual dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MR perfusion parameters and determine the association of DCE parameters with overall survival (OS) with the established predictive DSC parameter cerebral blood volume (CBV) in patients with newly diagnosed glioblastoma. Methods Perfusion data were analyzed retrospectively, and included scans performed preoperatively at 3.0 Tesla in 37 patients (25 males, 12 females, 39–83 years, median 65) later diagnosed with glioblastoma. All patients received standard treatment consisting of surgery and radiochemotherapy. Images were spatially coregistered and maximum region of interest‐based DCE and DSC parameter measurements compared and thresholds identified using multivariate linear regression, Pearson's correlation coefficients and using receiver operating characteristic analysis. Survival analysis was performed using Kaplan‐Meier curves. Results While both, elevated volume transfer constant (K trans ) (>0.29 min −1 ; P = 0.041) and CBV (>23.7 mL/100 mL; P < 0.001) were significantly associated with OS, elevated CBV was associated with worse OS compared with elevated K trans . K trans was significantly correlated with the leakage correction factor K 2 but not with CBV. Conclusion The combined use of DSC and DCE MR perfusion may provide additional information of prognostic value for glioblastoma patient survival prediction. As K trans was not tightly coupled to CBV, both parameters may reflect different stages in the pathogenetic sequence of glioblastoma growth. J. Magn. Reson. Imaging 2015;42:87–96 . © 2014 Wiley Periodicals, Inc .