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Differences in hyperpolarized 3 He ventilation imaging after 4 years in adults with cystic fibrosis
Author(s) -
Paulin Gregory A.,
Svenningsen Sarah,
Jobse Brian N.,
Mohan Sindu,
Kirby Miranda,
Lewis James F.,
Parraga Grace
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24744
Subject(s) - spirometry , medicine , cystic fibrosis , plethysmograph , vital capacity , magnetic resonance imaging , pulmonary function testing , ventilation (architecture) , cardiology , nuclear medicine , lung function , asthma , radiology , lung , diffusing capacity , mechanical engineering , engineering
Purpose To evaluate cystic fibrosis (CF) subjects over 4 years using 3 He magnetic resonance imaging (MRI), pulmonary function tests, and track hospitalization and physician visits. Materials and Methods Five CF adults provided written informed consent to an approved protocol and underwent MRI, spirometry, and plethysmography at baseline, 7 days, and 4 ± 1 years later. 3 He MRI ventilation defect percent (VDP) was generated for all subjects and timepoints. Results After 4 years, mean forced expiratory volume in 1 second / forced vital capacity (FEV 1 /FVC) was lower ( P = 0.01) in all subjects and there were no other pulmonary function test changes. Two CF adults showed significantly elevated (worse) 3 He VDP at baseline and after 4 years they had significantly greater (worsened) VDP ( P = 0.02), without a significant FEV 1 decline ( P = 0.06) but with a greater number of exacerbations ( P < 0.05). Baseline VDP strongly correlated with FEV 1 (r 2 = 0.98, P = 0.0007) at 4‐year follow‐up. Conclusion For two CF subjects, VDP was significantly worse at baseline and worsened over 4 years, which was in agreement with a greater number of hospitalizations and clinic visits. These results are limited by the very small sample size, but the strong VDP correlation with longitudinal changes in FEV 1 generates the hypothesis that abnormal VDP may temporally precede FEV 1 decline in CF subjects; this must be tested in a larger CF study. J. Magn. Reson. Imaging 2015;41:1701–1707 . © 2014 Wiley Periodicals, Inc .