Premium
Noncontrast myocardial T 1 mapping using cardiovascular magnetic resonance for iron overload
Author(s) -
Sado Daniel M.,
Maestrini Viviana,
Piechnik Stefan K.,
Banypersad Sanjay M.,
White Steven K.,
Flett Andrew S.,
Robson Matthew D.,
Neubauer Stefan,
Ariti Cono,
Arai Andrew,
Kellman Peter,
Yamamura Jin,
Schoennagel Bjoern P.,
Shah Farrukh,
Davis Bernard,
Trompeter Sara,
Walker Malcolm,
Porter John,
Moon James C.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24727
Subject(s) - reproducibility , medicine , magnetic resonance imaging , nuclear medicine , clinical trial , radiology , cardiology , statistics , mathematics
Purpose To explore the use and reproducibility of magnetic resonance‐derived myocardial T 1 mapping in patients with iron overload. Materials and Methods The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty‐five patients underwent repeat scanning for reproducibility. T 1 mapping used the shortened modified Look–Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. T 2 * was performed using a commercially available sequence. The analysis of the T 2 * interstudy reproducibility data was performed by two different research groups using two different methods. Results Myocardial T 1 was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, P < 0.0001). Myocardial T 1 correlated with T 2 * (R = 0.79, P < 0.0001). No patient with low T 2 * had normal T 1 , but 32% ( n = 28) of cases characterized by a normal T 2 * had low myocardial T 1 . Interstudy reproducibility of either T 1 sequence was significantly better than T 2 *, with the results suggesting that the use of T 1 in clinical trials could decrease potential sample sizes by 7‐fold. Conclusion Myocardial T 1 mapping is an alternative method for cardiac iron quantification. T 1 mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of T 1 has potential implications for clinical trial design and therapeutic monitoring. J. Magn. Reson. Imaging 2015;41:1505–1511 . © 2014 Wiley Periodicals, Inc .