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Endogenous contrast MRI of cardiac fibrosis: Beyond late gadolinium enhancement
Author(s) -
van Oorschot Joep W.M.,
Gho Johannes M.I.H.,
van Hout Gerardus P.J.,
Froeling Martijn,
Jansen of Lorkeers Sanne J.,
Hoefer Imo E.,
Doevendans Pieter A.,
Luijten Peter R.,
Chamuleau Steven A.J.,
Zwanenburg Jaco J.M.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24715
Subject(s) - medicine , gadolinium , fibrosis , magnetic resonance imaging , myocardial fibrosis , clinical practice , cardiac fibrosis , cardiac magnetic resonance , radiology , chemistry , family medicine , organic chemistry
The aim of this review is to provide an overview of detection of cardiac fibrosis with MRI using current standards and novel endogenous MRI techniques. Assessment of cardiac fibrosis is important for diagnosis, prediction of prognosis and follow‐up after therapy. During the past years, progress has been made in fibrosis detection using MRI. Cardiac infarct size can be assessed noninvasively with late gadolinium enhancement. Several methods for fibrosis detection using endogenous contrast have been developed, such as native T 1 ‐mapping, T 1ρ ‐mapping, Magnetization transfer imaging, and T 2 *‐mapping. Each of these methods will be described, providing the basic methodology, showing potential applications from applied studies, and discussing the potential and challenges or pitfalls. We will also identify future steps and developments that are needed for bringing these methods to the clinical practice. J. Magn. Reson. Imaging 2015;41:1181–1189. © 2014 Wiley Periodicals, Inc.