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Dynamic contrast‐enhanced MRI of gastric cancer: Correlation of the perfusion parameters with pathological prognostic factors
Author(s) -
Joo Ijin,
Lee Jeong Min,
Han Joon Koo,
Yang HanKwang,
Lee HyukJoon,
Choi Byung Ihn
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24711
Subject(s) - medicine , magnetic resonance imaging , nuclear medicine , cancer , dynamic contrast , pathological , wilcoxon signed rank test , rank correlation , mann–whitney u test , dynamic contrast enhanced mri , radiology , spearman's rank correlation coefficient , pathology , mathematics , statistics
Purpose To investigate the feasibility of dynamic, contrast‐enhanced, magnetic resonance imaging (DCE‐MRI) for perfusion quantification of gastric cancers, and to correlate the DCE‐MRI parameters with the pathological prognostic factors. Materials and Methods This prospective study was approved by our Institutional Review Board. Twenty‐seven patients with gastric cancers underwent DCE‐MRI using a free‐breathing, radial, gradient‐echo (GRE) sequence with k ‐space weighted image contrast (KWIC) reconstruction on a 3T scanner. The DCE‐MRI parameters (volume transfer coefficient [K trans ], reverse reflux rate constant [K ep ], extracellular extravascular volume fraction [V e ], and initial area under the gadolinium concentration curve during the first 60 seconds [iAUC]) of gastric cancer and normal wall were measured and compared with each other using the Wilcoxon signed rank test. The relationship between the DCE‐MRI parameters of gastric cancer and the pathological prognostic factors were evaluated using the Mann–Whitney test or the Spearman rank correlation test. Results DCE‐MRIs were of diagnostic quality in 22 patients (81.5%). V e and iAUC were significantly higher in gastric cancer than in normal gastric wall ( P < 0.05). V e showed significant positive correlation with T‐staging of gastric cancers ( P < 0.05). K trans was significantly correlated with the grades of epidermal growth‐factor receptor expression ( P < 0.05). Conclusion DCE‐MRI using a radial GRE with KWIC reconstruction is feasible for quantification of the perfusion dynamics of gastric cancers, and the DCE‐MRI parameters of gastric cancers may provide prognostic information. J. Magn. Reson. Imaging 2015;41:1608–1614 . © 2014 Wiley Periodicals, Inc .