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Prognostic performance of preoperative gadoxetic acid‐enhanced MRI in resectable hepatocellular carcinoma
Author(s) -
Shim Ju Hyun,
Han Seungbong,
Shin Yong Moon,
Lee YoungJoo,
Lee SungGyu,
Kim Kang Mo,
Lim YoungSuk,
Lee Han Chu
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24660
Subject(s) - gadoxetic acid , medicine , hepatocellular carcinoma , magnetic resonance imaging , propensity score matching , radiology , proportional hazards model , retrospective cohort study , cohort , hepatectomy , resection , gastroenterology , surgery , gadolinium dtpa
Purpose To assess the impact of preoperative evaluation by gadoxetic acid‐enhanced magnetic resonance imaging (MRI) on early recurrence outcomes after hepatocellular carcinoma (HCC) resection. Materials and Methods The retrospective study included two groups of Child‐Pugh class A patients who underwent curative liver resection for a single HCC; in one group the HCC was identified by dynamic computed tomography (CT) and gadoxetic acid‐enhanced MRI ( n = 174; MRI group); in the other by dynamic CT only ( n = 416; non‐MRI group). We compared the two groups with respect to recurrence‐free survival after propensity score matching (162 pairs). Results In the matched cohorts, disease‐free survival rates for overall and intrahepatic recurrence were 92.6% and 91.9% at 1 year and 78.3% and 79.4% at 2 years, respectively, for the MRI group versus 82.7% and 82.7% at 1 year and 67.2% and 70.4% at 2 years, respectively, for the non‐MRI group ( P < 0.05). Multivariate Cox analyses revealed that the MRI group was independently superior to the non‐MRI group in terms of risk of overall and intrahepatic recurrence at 1 and 2 years in the pooled cohort ( P < 0.05). Conclusion Gadoxetic acid‐enhanced MRI evaluation is more useful than dynamic CT for identifying good surgical candidates at low risk of early recurrence following hepatic resection for HCC. J. Magn. Reson. Imaging 2015;41:1115–1123 . © 2014 Wiley Periodicals, Inc .