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Improved multislice perfusion imaging with velocity‐selective arterial spin labeling
Author(s) -
Zun Zungho,
Hargreaves Brian A.,
Rosenberg Jarrett,
Zaharchuk Greg
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24652
Subject(s) - arterial spin labeling , multislice , moyamoya disease , cerebral blood flow , medicine , sharpening , nuclear medicine , biomedical engineering , radiology , computer science , cardiology , artificial intelligence
Purpose To improve the multislice performance of velocity‐selective arterial spin labeling (VS‐ASL) imaging for cerebral blood flow (CBF) measurement such that it might be routinely applied for clinical applications with whole brain coverage. Materials and Methods VS‐ASL was performed with improvements such as timing optimization, stimulated echo removal, and slice profile sharpening. Each improvement was evaluated in volunteers by measuring temporal noise in the CBF measurement. VS‐ASL with all these improvements was performed in 20 patients with Moyamoya disease some of whom also underwent xenon‐enhanced CT (xeCT) imaging which was the reference standard for CBF measurement. Results Sequence timing optimization and inter‐slice crosstalk reduction using stimulated echo removal and slice profile sharpening all contributed to reduction of temporal noise. VS‐ASL imaging with all these improvements performed in Moyamoya disease patients showed significant reduction of temporal noise ( P < 0.0001) and increased correlation coefficient with xeCT CBF imaging (from 0.07 to 0.62). Conclusion We demonstrated that timing optimization, stimulated echo removal, and slice profile improvement have a large effect on image quality and robustness of VS‐ASL in clinical imaging applications. J. Magn. Reson. Imaging 2015;41:1422–1431. © 2014 Wiley Periodicals, Inc.