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Principles of T 2 *‐weighted dynamic susceptibility contrast MRI technique in brain tumor imaging
Author(s) -
Shiroishi Mark S.,
Castellazzi Gloria,
Boxerman Jerrold L.,
D'Amore Francesco,
Essig Marco,
Nguyen Thanh B.,
Provenzale James M.,
Enterline David S.,
Anzalone Nicoletta,
Dörfler Arnd,
Rovira Àlex,
Wintermark Max,
Law Meng
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24648
Subject(s) - grading (engineering) , magnetic resonance imaging , brain tumor , medicine , dynamic contrast , radiology , neuroimaging , perfusion scanning , dynamic contrast enhanced mri , nuclear medicine , medical physics , perfusion , pathology , civil engineering , psychiatry , engineering
Dynamic susceptibility contrast magnetic resonance imaging (DSC‐MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor hemodynamics. DSC‐MRI parameters can be helpful in many aspects, including tumor grading, prediction of treatment response, likelihood of malignant transformation, discrimination between tumor recurrence and radiation necrosis, and differentiation between true early progression and pseudoprogression. This review aims to provide a conceptual overview of the underlying principles of DSC‐MRI of the brain for clinical neuroradiologists, scientists, or students wishing to improve their understanding of the technical aspects, pitfalls, and controversies of DSC perfusion MRI of the brain. Future consensus on image acquisition parameters and postprocessing of DSC‐MRI will most likely allow this technique to be evaluated and used in high‐quality multicenter studies and ultimately help guide clinical care. J. Magn. Reson. Imaging 2015;41:296–313. © 2013 Wiley Periodicals, Inc .