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Early radiation‐induced changes evaluated by intravoxel incoherent motion in the major salivary glands
Author(s) -
Marzi Simona,
Forina Chiara,
Marucci Laura,
Giovinazzo Giuseppe,
Giordano Carolina,
Piludu Francesca,
Landoni Valeria,
Spriano Giuseppe,
Vidiri Antonello
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24626
Subject(s) - intravoxel incoherent motion , nuclear medicine , medicine , perfusion , radiation therapy , effective diffusion coefficient , radiology , magnetic resonance imaging
Purpose To investigate the potential of intravoxel incoherent motion (IVIM) MRI for early evaluation of irradiated major salivary glands. Materials and Methods Thirty‐four patients with head‐neck cancer were included in a prospective study. All patients underwent three serial IVIM‐MRI: before, half‐way through, and at the end of radiotherapy (RT). Apparent diffusion coefficient (ADC), ADC low derived in the low b ‐value range, perfusion fraction f , and pure diffusion coefficient D were estimated. Pretreatment values and early changes of diffusion parameters were correlated with parotid mean dose (D mean ) and volume reduction after RT. Results Changes in diffusion parameters over time were all significant ( P < 0.001 for ADC, ADC low , and D, P = 0.003 for f ). Variations of ADC, ADC low , and f were not correlated with D mean ( P = 0.089, P = 0.252 and P = 0.884, respectively), whereas a significant relationship was found between changes in D and D mean (r = 0.197 with CI95% = 0.004–0.375, P = 0.046). Pretreatment f and D mean were the best independent predictors for the percentage shrinkage ( P = 0.0003 and 0.0597 respectively; R 2 = 0.391). Conclusion Early changes of irradiated major salivary glands can be noninvasively evaluated by IVIM‐MRI. Perfusion‐related coefficients in conjunction with dosimetric information increase our capability to predict the change in parotid volume and hence, if further validated, guide treatment strategy in RT. J. Magn. Reson. Imaging 2015;41:974–982 . © 2014 Wiley Periodicals, Inc .