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Manganese‐enhanced MRI of minimally gadolinium‐enhancing breast tumors
Author(s) -
Ganesh Tameshwar,
Mokhtari Reza Bayat,
Alhamami Mosa,
Yeger Herman,
Cheng HaiLing Margaret
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24608
Subject(s) - vascularity , gadolinium , histology , medicine , magnetic resonance imaging , nuclear medicine , necrosis , pathology , radiology , chemistry , organic chemistry
Purpose To investigate the potential of manganese (Mn)‐enhanced MRI for sensitive detection and delineation of tumors that demonstrate little enhancement on Gd‐DTPA. Materials and Methods Eighteen nude rats bearing 1 to 2 cm in diameter orthotopic breast tumors (ZR75 and LM2) were imaged on a 3 Tesla (T) clinical scanner. Gd‐DTPA was administered intravenously and MnCl 2 subcutaneously, both at 0.05 mmol/kg. T 1 ‐weighted imaging and T 1 measurements were performed precontrast, 10 min post‐Gd‐DTPA, and 24 h post‐MnCl 2 . Tumors were excised and histologically assessed using H&E (composition and necrosis) and CD34 (vascularity). Results Most tumors (78%) demonstrated little enhancement (< 20% change in R 1 ) on Gd‐DTPA. MnCl 2 administration achieved greater and more uniform enhancement throughout the tumor mass (i.e., not restricted to the tumor periphery), with R 1 changing over 20% in 72% of tumors. MnCl 2 ‐induced R 1 changes compared with Gd‐induced changes were significantly greater in both ZR75 ( P < 0.01) and LM2 tumors ( P < 0.05). Histology confirmed very low vascularity in both tumor models, and necrotic areas were well delineated only on Mn‐enhanced MRI. Conclusion Mn‐enhanced MRI is a promising approach for detection of low‐Gd‐enhancing tumors. J. Magn. Reson. Imaging 2015;41:806–813. © 2014 Wiley Periodicals, Inc.