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Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements
Author(s) -
Orsi Gergely,
Aradi Mihály,
Nagy Szilvia Anett,
Perlaki Gábor,
Trauninger Anita,
Bogner Péter,
Janszky József,
Illés Zsolt,
Dóczi Tamás,
Pfund Zoltán,
Schwarcz Attila
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24580
Subject(s) - migraine , multiple sclerosis , white matter , diffusion mri , medicine , magnetic resonance imaging , hyperintensity , effective diffusion coefficient , nuclear medicine , pathology , radiology , psychiatry
Purpose To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b‐value biexponential diffusion measurements. Materials and Methods Diffusion‐weighted images were acquired on a 3.0‐Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0–1000 s/mm 2 ) and biexponential (0–5000 s/mm 2 ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal‐appearing white matter of patients and in the white matter of controls. Results High lesional ADC mono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10 −4 mm 2 /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADC fast , ADC slow , and P slow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10 −4 mm 2 /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively). Conclusion Biexponential diffusion analysis may help to differentiate multiple sclerosis‐related white matter lesions from migraine‐related ones. J. Magn. Reson. Imaging 2015;41:676–683. © 2014 Wiley Periodicals, Inc.