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Cisterna chyli in autosomal dominant polycystic kidney disease
Author(s) -
Thimmappa Nanda Deepa,
Blumenfeld Jon D.,
Cerilles Michelle Ann C.,
Dunning Allison,
Donahue Stephanie L.,
Bobb Warren O.,
Zhang Hong Lei,
Prince Martin R.
Publication year - 2015
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24527
Subject(s) - medicine , autosomal dominant polycystic kidney disease , cisterna , renal function , radiology , cyst , urology , genetics , biology , cell , golgi apparatus
Purpose After observing prominent cisterna chyli in several patients with autosomal dominant polycystic kidney disease (ADPKD), we investigated the potential association of cistern chyli enlargement with ADPKD. Materials and Methods Retrospective, cross‐sectional analysis of abdominal and pelvic MRI at 1.5 Tesla (T) in 70 ADPKD patients (male 44.3%, 20–83 years, median = 53 years) were compared with 70 age and gender matched control subjects without ADPKD, cirrhosis, or cholestasis. Cisterna chyli diameter was measured on axial single shot fast spin echo (SSFSE) images at the level of T12–L2 and evaluated by multivariable regression models with covariates including estimated glomerular filtration rate (eGFR), total kidney volume (TKV), renal cyst fraction (cyst volume/kidney volume), and liver volume. Results Subjects with ADPKD had larger median cisterna chyli diameter compared with those without ADPKD (6.1 mm versus 3.4 mm, P < 0.0001). The prevalence of cisterna chyli enlargement more than the median (3.4 mm), was greater in ADPKD than in controls (99% versus 51%, P < 0.0001). On univariate analysis, cisterna chyli diameter was inversely correlated with eGFR (r = −0.41; P < 0.0001) and directly correlated with TKV (r = 0.57; P < 0.0001), total renal cyst fraction (r = 0.61; P < 0.001), and liver volume (r = 0.17; P = 0.040). Multivariable linear regression modeling found a significant association of cisterna chyli diameter with ADPKD diagnosis (B = 2.14; 95% confidence interval [CI]: 0.05–4.23; P = 0.04). Logistic regression analysis confirmed the association of ADPKD with an enlarged cisterna chyli diameter (odds ratio = 68.4; 95%CI: 8.9–524, P < 0.0001). Conclusion Enlarged cisterna chyli is highly prevalent in ADPKD patients but not in age and gender‐matched controls. J. Magn. Reson. Imaging 2015;41:142–148. © 2014 Wiley Periodicals, Inc .