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Measurement of apparent diffusion coefficient with simultaneous MR/positron emission tomography in patients with peritoneal carcinomatosis: Comparison with 18F‐FDG‐PET
Author(s) -
Schwenzer Nina F.,
Schmidt Holger,
Gatidis Sergios,
Brendle Cornelia,
Müller Mark,
Königsrainer Ingmar,
Claussen Claus D.,
Pfannenberg Anna C.,
Schraml Christina
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24497
Subject(s) - peritoneal carcinomatosis , positron emission tomography , effective diffusion coefficient , nuclear medicine , medicine , positron emission , positron , radiology , magnetic resonance imaging , physics , cancer , nuclear physics , colorectal cancer , electron
Purpose To characterize peritoneal carcinomatosis (PC) of different histologically proven primary tumors based on diffusion‐weighted imaging (DWI) and 18 F‐FDG positron emission tomography (PET). Materials and Methods Forty‐one patients underwent simultaneous MR/PET after clinically indicated 18 F‐FDG‐PET/CT. For all patients, histology of the primary tumor was obtained. MR protocol comprised anatomical imaging and axial DWI. Apparent diffusion coefficient (ADC) maps and FDG‐PET were co‐registered for evaluation of ADC and standard uptake value (SUV) of peritoneal lesions. Both lesion‐ and patient‐based analysis was performed. Up to four peritoneal lesions were evaluated per patient. Mean and maximum standard uptake value (SUV mean , SUV max ), mean and minimum ADC (ADC mean , ADC min ) of each lesion were assessed. Spearman rank correlation (r s ) of ADC and SUV were calculated. SUV and ADC of ovarian and colorectal cancer lesions were compared using Wilcoxon test. Results Measurable lesions (n = 52) were found in 20 of 41 PC patients. Moderate, but significant correlation existed between ADC and SUV in the lesion‐based as well as the patient‐based analysis (lesion‐based: SUV mean versus ADC mean r s = −0.58; SUV max versus ADC min r s = −0.56, all P < 0.0001; patient‐based: SUV mean versus ADC mean r s = −0.64, P = 0.002; SUV max versus ADC min r s = −0.60, P = 0.005). ADC and SUV differed significantly between ovarian and colorectal cancer lesions (ADC min : P < 0.0001; ADC mean : P < 0.0001; SUV max : P = 0.002; SUV mean : P = 0.005). Overall, mucinous tumor entities showed a tendency to higher ADC and lower SUV. Conclusion PC lesions showed significant differences in glucose uptake and diffusion characteristics depending on primary tumor histology. These differences should be considered when interpreting FDG‐PET and DWI in PC patients. J. Magn. Reson. Imaging 2014;40:1054–1055 . © 2013 Wiley Periodicals, Inc .