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Diagnostic efficacy of the diffusion weighted imaging in the characterization of different types of breast lesions
Author(s) -
Kul Sibel,
Eyuboglu Ilker,
Cansu Aysegul,
Alhan Etem
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24491
Subject(s) - medicine , cutoff , lesion , radiology , diffusion mri , nuclear medicine , effective diffusion coefficient , magnetic resonance imaging , pathology , physics , quantum mechanics
Purpose To evaluate the diagnostic efficacy of quantitative Diffusion‐weighted imaging (DWI) in the characterization of breast lesions of mass and non‐mass enhancement (NME) types. Materials and Methods After the institutional review board gave approval, DWI exams of 267 women with 212 suspicious masses, 73 NMEs were retrospectively analyzed. Apparent diffusion coefficients (ADCs) of benign and malignant lesions were compared. Cutoff values were obtained by receiver operating characteristics analysis. Diagnostic accuracies of DWI for masses and NMEs were compared with the use of Chi‐square test. The effect of the lesions histologic subtypes and size on diagnostic accuracies was evaluated. Results ADCs were significantly lower in malignants than in benigns for both masses (0.75 versus 1.21 × 10 −3 mm 2 /s,) and NMEs (0.79 versus 1.06 × 10 −3 mm 2 /s)( P < 0.001). Cutoff value was 0.90 × 10 −3 mm 2 /s for both lesion types. The accuracy of DWI was lower in NMEs (76.7%) than masses (89.2%) ( P = 0.008) unrelated to lesion size. There was more overlap in ADCs of the benign and malignant NMEs due to the lower ADCs of the benign histologies of this group. Conclusion Despite the lower diagnostic accuracy of DWI in NMEs, it could be helpful in the characterization of suspicious breast lesions of both mass and NME types. J. Magn. Reson. Imaging 2014;40:1158–1164 . © 2013 Wiley Periodicals, Inc .