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Quantification of cerebral blood flow in healthy volunteers and type 1 diabetic patients: Comparison of MRI arterial spin labeling and [ 15 O]H 2 O positron emission tomography (PET)
Author(s) -
Golen Larissa W.,
Kuijer Joost P.A.,
Huisman Marc C.,
IJzerman Richard G.,
Barkhof Frederik,
Diamant Michaela,
Lammertsma Adriaan A.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24484
Subject(s) - cerebral blood flow , nuclear medicine , positron emission tomography , medicine , magnetic resonance imaging , arterial spin labeling , white matter , blood flow , positron , nuclear magnetic resonance , radiology , physics , quantum mechanics , electron
Purpose To compare cerebral blood flow (CBF) values measured using magnetic resonance imaging (MRI) arterial spin labeling (ASL) with those obtained with [ 15 O]H 2 O positron emission tomography (PET), the gold standard for measuring CBF in vivo. Materials and Methods Data were collected in 11 healthy men and in 20 age‐ and body mass index (BMI)‐matched type 1 diabetic men. Pseudo‐continuous ASL (PCASL) data were acquired at 3 T and [ 15 O]H 2 O PET scans were acquired using a high‐resolution PET scanner. Input functions were obtained using on‐line arterial blood sampling. Whole brain and regional CBF values were compared. Results For both modalities, whole brain CBF was similar in both subject groups. In groups combined, average whole brain CBF was 0.30 ± 0.05 mL·cm −3 ·min −1 for [ 15 O]H 2 O PET and 0.34 ± 0.05 mL·cm −3 ·min −1 for ASL MRI ( P < 0.01). A significant correlation between methods was observed for whole brain, gray and white matter. In 12 out of 33 brain regions a significant difference between methods was observed. Conclusion PCASL provides CBF values that correlate with [ 15 O]H 2 O PET‐derived values, but is less accurate. PCASL may be an attractive alternative when absolute quantification is not needed. J. Magn. Reson. Imaging 2014;40:1300–1309 . © 2013 Wiley Periodicals, Inc .