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Gadolinium‐free T 1 contrast agents for MRI: Tunable pharmacokinetics of a new class of manganese porphyrins
Author(s) -
Cheng HaiLing Margaret,
Haedicke Inga E.,
Cheng Weiran,
Tchouala Nofiele Joris,
Zhang Xiaoan
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24483
Subject(s) - gadolinium , pharmacokinetics , magnetic resonance imaging , contrast (vision) , clearance , nuclear medicine , kidney , medicine , biodistribution , spin–lattice relaxation , mri contrast agent , chemistry , nuclear magnetic resonance , radiology , urology , biochemistry , physics , organic chemistry , artificial intelligence , nuclear quadrupole resonance , computer science , in vitro
Purpose To evaluate a new class of manganese porphyrins with tunable pharmacokinetics as potential gadolinium (Gd)‐free T 1 agents for contrast‐enhanced magnetic resonance imaging (MRI). Materials and Methods Two new contrast agents, MnTCP and MnP2, were evaluated in four female rats. MRI was performed daily up to 3 days postinjection (0.05 mmol/kg) on a 3 T clinical scanner. T 1 relaxation times and dynamic contrast‐enhanced MRI were performed to assess contrast enhancement and clearance in blood, heart, liver, kidney, and muscle. Results Relative T 1 decreases were similar for MnTCP and Gd‐DTPA in all tissues but were significantly larger ( P < 0.05) for MnP2 in blood, heart, kidney, and liver (2–6‐fold larger). Clearance of MnTCP was similar to Gd‐DTPA, with T 1 returning to baseline by 40 minutes and complete elimination in 1 day. MnP2 was cleared from blood after 2 days and sustained a lowered T 1 in other tissues for at least 1 hour ( P < 0.05). The maximum enhancement, slope, and time‐to‐peak were similar between contrast agents. Only the parameter AUC 60 differed, with MnP2 yielding the largest AUC 60 values primarily through longer retention in tissue. Conclusion MnTCP and MnP2 offer distinct applications as Gd‐free T 1 contrast agents. MnTCP behaves like a Gd‐DTPA analog, while MnP2 provides significantly greater and longer positive signal enhancement. J. Magn. Reson. Imaging 2014;40:1474–1480 . © 2013 Wiley Periodicals, Inc .