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Response to chemotherapy in gastric adenocarcinoma with diffusion‐weighted MRI and 18 F‐FDG‐PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade
Author(s) -
Giganti Francesco,
De Cobelli Francesco,
Canevari Carla,
Orsenigo Elena,
Galliva Francesca,
Esposito Antonio,
Castiglioni Isabella,
Ambrosi Alessandro,
Albarello Luca,
Mazza Elena,
Gianolli Luigi,
Staudacher Carlo,
Del Maschio Alessandro
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24464
Subject(s) - effective diffusion coefficient , nuclear medicine , standardized uptake value , medicine , diffusion mri , positron emission tomography , magnetic resonance imaging , radiology
Purpose To assess whether changes in diffusion‐weighted MRI (DW‐MRI) and 18 F‐fluoro‐2‐deoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA). Materials and Methods Seventeen patients underwent both DW‐MRI and 18 F‐FDG‐PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC‐SUV BW‐mean ) were evaluated and compared with histopathological TRG. Results Pre‐ and post‐NT and percentage changes for ADC and PVC‐SUV BW‐mean were assessed. Post‐NT ADC and ΔADC showed a significant inverse correlation with TRG ( r = −0.71; P = 0.0011 and r = −0.78; P = 0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1–2‐3) and nonresponders (TRG 4–5) ( P = 0.0009; P = 0.000082, respectively). No correlations with TRG were found for pre‐NT ADC and for all PVC‐SUV BW‐mean values as well as between ΔADC and Δ PVC‐SUV BW‐mean . Conclusion DW‐MRI seems more accurate than 18 F‐FDG‐PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA. J. Magn. Reson. Imaging 2014;40:1147–1157 . © 2013 Wiley Periodicals, Inc .