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Perfusion measurements of the calf in patients with peripheral arterial occlusive disease before and after percutaneous transluminal angioplasty using Mr arterial spin labeling
Author(s) -
Grözinger Gerd,
Pohmann Rolf,
Schick Fritz,
Grosse Ulrich,
Syha Roland,
Brechtel Klaus,
Rittig Kilian,
Martirosian Petros
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24463
Subject(s) - reactive hyperemia , medicine , perfusion , percutaneous , peripheral , ankle , cardiology , blood flow , surgery
Purpose To evaluate muscle perfusion in patients with peripheral arterial occlusive disease (PAOD) before and after percutaneous transluminal angioplasty (PTA) of the limb by means of MR arterial spin labeling (ASL) perfusion measurements during reactive hyperemia. Materials and Methods Ten patients with symptomatic PAOD affecting the iliac or femoral vessels were investigated before and after PTA. A pseudo‐continuous arterial spin labeling (PCASL) MR technique was applied. Perfusion was measured in soleus and tibialis anterior muscle during reactive hyperemia. Key parameters such as mean perfusion value (P hyp ), time‐to‐peak (TTP) and duration of hyperemia (T hyp ) describing the perfusion signal curve were examined. Results Between baseline and post‐PTA, P hyp increased in both muscle groups. At the same time, TTP and T hyp decreased in both muscle groups. At the same time the clinically assessed ankle brachial index (ABI) increased from 0.56 ± 0.10 to 0.83 ± 0.15. The impaired pain‐free walking distance improved in all patients. Conclusion PCASL MRI can detect changes of the key perfusion parameters P hyp , TTP, and T hyp after successful PTA of the calf muscles during reactive hyperemia and seems to be a promising tool for monitoring of interventional treatments. J. Magn. Reson. Imaging 2014;40:980–987 . © 2013 Wiley Periodicals, Inc .