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Reproducibility of MRI renal artery blood flow and BOLD measurements in patients with chronic kidney disease and healthy controls
Author(s) -
Khatir Dinah S.,
Pedersen Michael,
Jespersen Bente,
Buus Niels H.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24446
Subject(s) - reproducibility , medicine , kidney disease , kidney , coefficient of variation , renal artery , blood flow , inhalation , cardiology , renal medulla , nuclear medicine , pathology , urology , anesthesia , chemistry , chromatography
Purpose Determine the reproducibility of renal artery blood flow (RABF) and blood‐oxygenation level dependent (R 2 *) in patients with chronic kidney disease (CKD) and healthy controls. Materials and Methods RABF and R 2 * were measured in 11 CKD patients and 9 controls twice with 1‐ to 2‐week interval. R 2 * in the cortex and medulla were determined after breathing atmospheric air and 100% oxygen. Reproducibility was evaluated by coefficients of variation (CV), limits of agreements and intra‐class coefficient calculated by variance components by maximum likelihood modeling. Results Single‐kidney RABF (mL/min) for patients was: 170 ± 130 and 186 ± 137, and for controls: 365 ± 119 and 361 ± 107 ( P < 0.05 versus patients), for first and second scans, respectively. RABF measurements were reproducible with a CV of 12.9% and 8.3% for patients and controls, respectively. Renal cortical R 2 * was: 13.6 ± 0.9 and 13.5 ± 1.2 in patients (CV = 8.0%), and 13.8 ± 1.6 and 14.0 ± 1.5 in controls (CV = 5.6%), while medullary R 2 *(s −1 ) was: 26.9 ± 2.0 and 27.0 ± 4.0 (CV = 8.0%) in patients, and 26.0 ± 2.4 and 26.1 ± 2.1 (CV = 3.6%) in controls, for first and second scans, respectively. In both groups R 2 * in medulla decreased after breathing 100% oxygen. Conclusion The reproducibility was high for both RABF and R 2 * in patients and controls, particularly in the cortex. Inhalation of 100% oxygen reduced medullary R 2 *. J. Magn. Reson. Imaging 2014;40:1091–1098 . © 2013 Wiley Periodicals, Inc .