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Effect of intravenous gadolinium‐DTPA on diffusion‐weighted imaging of brain tumors: A short temporal interval assessment
Author(s) -
Li Xiang,
Qu JinRong,
Luo JunPeng,
Li Jing,
Zhang HongKai,
Shao NanNan,
Kwok Keith,
Zhang ShouNing,
Li Yanle,
Liu CuiCui,
Zee ChiShing,
Li HaiLiang
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24386
Subject(s) - medicine , gadolinium , nuclear medicine , effective diffusion coefficient , glioma , brain tumor , magnetic resonance imaging , brain tissue , parenchyma , radiology , pathology , materials science , cancer research , metallurgy
Purpose To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval. Materials and Methods Forty‐four DWI studies using b values of 0 and 1000 s/mm 2 were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd‐DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions. The signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and apparent diffusion coefficient (ADC) values of the brain tumor lesions and normal brain tissues were measured on pre‐ and postcontrast images. Statistical analysis using paired t‐test between precontrast and postcontrast data were obtained on three brain tumors and normal brain tissue. Results The SNR and CNR of brain tumors and the SNR of normal brain tissue showed no statistical differences between pre‐ and postcontrast ( P > 0.05). The ADC values on the three cases of brain tumors demonstrated significant initial increase on the immediate time point ( P < 0.01) and decrease on following the 1 min time point ( P < 0.01) after contrast. Significant decrease of ADC value was still found at 3min and 5min time point in the meningioma group ( P < 0.01) with gradual normalization over time. The ADC values of normal brain tissues demonstrated significant initial elevation on the immediately postcontrast DWI sequence ( P < 0.01). Conclusion Contrast medium can cause a slight but statistically significant change on the ADC value within a short temporal interval after the contrast administration. The effect is both time and lesion‐type dependent. J. Magn. Reson. Imaging 2014;40:616–621 . © 2013 Wiley Periodicals, Inc .