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Spatial distribution of MRI‐determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease
Author(s) -
Bonekamp Susanne,
Tang An,
Mashhood Arian,
Wolfson Tanya,
Changchien Christopher,
Middleton Michael S.,
Clark Lisa,
Gamst Anthony,
Loomba Rohit,
Sirlin Claude B.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24321
Subject(s) - nonalcoholic fatty liver disease , medicine , nonalcoholic steatohepatitis , fatty liver , fraction (chemistry) , distribution (mathematics) , pathology , radiology , nuclear magnetic resonance , disease , chemistry , physics , mathematics , chromatography , mathematical analysis
Purpose To describe the spatial distribution of liver fat, using MRI‐estimated proton density fat fraction (PDFF), in adults with nonalcoholic fatty liver disease (NAFLD). Materials and Methods This Investigational Review Board‐approved, Health Insurance Portability and Accountability Act‐compliant study prospectively enrolled 50 adults (30 women, 20 men) with biopsy‐proven NAFLD. Hepatic PDFF was measured by low‐flip‐angle multiecho spoiled gradient‐recalled‐echo MRI at 3 Tesla. Three nonoverlapping regions of interest were placed within each liver segment. Statistical analyses included Pearson's correlation, multivariable linear regression, and permutation‐based paired tests. Results The study population's mean whole‐liver PDFF was 16.1% (range: 1.6–39.6%). The mean whole‐liver PDFF variability was 1.9% (range: 0.7–4.5%). Higher variability was associated with higher PDFF ( r = 0.34; P = 0.0156). The mean PDFF was significantly higher in the right lobe than the left (16.5% versus 15.3%, P = 0.0028). The mean PDFF variability was higher in the left lobe than the right (1.86% versus 1.28%; P < 0.0001). Segment II had the lowest mean segmental PDFF (14.8%); segment VIII had the highest (16.7%). Segments V (0.71%) and VI (0.70%) had the lowest mean segmental PDFF variability; segment II had the highest (1.32%). Conclusion In adult NAFLD there are small but significant differences in fat content and variability between lobes and some of the segments. J. Magn. Reson. Imaging 2014;39:1525–1532 . © 2013 Wiley Periodicals, Inc .