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Characterization of thalamo‐cortical association using amplitude and connectivity of functional MRI in mild traumatic brain injury
Author(s) -
Zhou Yongxia,
Lui Yvonne W.,
Zuo XiNian,
Milham Michael P.,
Reaume Joseph,
Grossman Robert I.,
Ge Yulin
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24310
Subject(s) - thalamus , traumatic brain injury , resting state fmri , neuroscience , functional connectivity , medicine , cortex (anatomy) , psychology , audiology , psychiatry
Purpose To examine thalamic and cortical injuries using fractional amplitude of low‐frequency fluctuations (fALFFs) and functional connectivity MRI (fcMRI) based on resting state (RS) and task‐related fMRI in patients with mild traumatic brain injury (MTBI). Materials and Methods Twenty‐seven patients and 27 age‐matched controls were recruited. The 3 Tesla fMRI at RS and finger tapping task were used to assess fALFF and fcMRI patterns. fALFFs were computed with filtering (0.01–0.08 Hz) and scaling after preprocessing. fcMRI was performed using a standard seed‐based correlation method, and delayed fcMRI (coherence) in frequency domain were also performed between thalamus and cortex. Results In comparison with controls, MTBI patients exhibited significantly decreased fALFFs in the thalamus (and frontal/temporal subsegments) and cortical frontal and temporal lobes; as well as decreased thalamo‐thalamo and thalamo‐frontal/ thalamo‐temporal fcMRI at rest based on RS‐fMRI (corrected P < 0.05). This thalamic and cortical disruption also existed at task‐related condition in patients. Conclusion The decreased fALFFs (i.e., lower neuronal activity) in the thalamus and its segments provide additional evidence of thalamic injury in patients with MTBI. Our findings of fALFFs and fcMRI changes during motor task and resting state may offer insights into the underlying cause and primary location of disrupted thalamo‐cortical networks after MTBI. J. Magn. Reson. Imaging 2014;39:1558–1568 . © 2013 Wiley Periodicals, Inc.