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Cerebral perfusion measured by dynamic susceptibility contrast MRI is reduced in patients with idiopathic normal pressure hydrocephalus
Author(s) -
Ziegelitz Doerthe,
Starck Göran,
Kristiansen David,
Jakobsson Martin,
Hultenmo Maria,
Mikkelsen Irene K.,
Hellström Per,
Tullberg Mats,
Wikkelsø Carsten
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24292
Subject(s) - medicine , cerebral blood flow , perfusion , white matter , hydrocephalus , cerebral perfusion pressure , cardiology , normal pressure hydrocephalus , grey matter , perfusion scanning , radiology , magnetic resonance imaging , nuclear medicine , dementia , disease
Purpose To demonstrate in idiopathic normal pressure hydrocephalus (iNPH) patients by dynamic susceptibility contrast MRI a reduced preoperative cerebral blood flow (CBF) which correlates with the severity of clinical symptoms and predicts shunt outcome. Materials and Methods In cortical, subcortical, periventricular regions and along peri‐and paraventricular profiles absolute perfusion values were estimated by multi‐slice DSC MRI in 21 iNPH patients and 16 age‐matched healthy individuals (HI). Relative CBF (rCBF), calculated with the occipital cortex as internal reference, was used for comparison between groups and for correlation analysis between regional rCBF and symptoms or outcome. Results iNPH patients showed significantly decreased rCBF in the basal medial frontal cortex, hippocampus, lentiform nucleus, periventricular white matter (PVWM), central grey matter and the global parenchyma as compared to HI. iNPH patients with higher preoperative rCBF in the PVWM performed better in clinical tests. A lower overall preoperative function resulted in a more obvious recovery after shunt insertion. Shunt‐responders had higher rCBF values in the basal medial frontal cortex than non‐responders. Conclusion DSC MRI perfusion is a potentially useful diagnostic tool in iNPH and perfusion based criteria might be possible predictors of shunt response. J. Magn. Reson. Imaging 2014;39:1533–1542 . © 2013 Wiley Periodicals, Inc .