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Hyperpolarized Helium‐3 MRI of exercise‐induced bronchoconstriction during challenge and therapy
Author(s) -
Kruger Stanley J.,
Niles David J.,
Dardzinski Bernard,
Harman Amy,
Jarjour Nizar N.,
Ruddy Marcella,
Nagle Scott K.,
Francois Christopher J.,
Sorkness Ronald L.,
Burton Ryan M.,
Munoz del Rio Alejandro,
Fain Sean B.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24272
Subject(s) - bronchoconstriction , medicine , spirometry , placebo , vital capacity , asthma , ventilation (architecture) , anesthesia , cardiology , airway , montelukast , nuclear medicine , lung , diffusing capacity , lung function , pathology , mechanical engineering , engineering , alternative medicine
Purpose To investigate the utility of hyperpolarized He‐3 MRI for detecting regional lung ventilated volume (V V ) changes in response to exercise challenge and leukotriene inhibitor montelukast, human subjects with exercise induced bronchoconstriction (EIB) were recruited. This condition is described by airway constriction following exercise leading to reduced forced expiratory volume in 1 second (FEV1) coinciding with ventilation defects on hyperpolarized He‐3 MRI. Materials and Methods Thirteen EIB subjects underwent spirometry and He‐3 MRI at baseline, postexercise, and postrecovery at multiple visits. On one visit montelukast was given and on two visits placebo was given. Regional V V was calculated in the apical/basilar dimension, in the anterior/posterior dimension, and for the entire lung volume. The whole lung V V was used as an end‐point and compared with spirometry. Results Postchallenge FEV1 dropped with placebo but not with treatment, while postchallenge V V dropped more with placebo than treatment. Sources of variability for V V included region (anterior/posterior), scan, and treatment. V V correlated with FEV1/ forced vital capacity (FVC) and forced expiratory flow between 25 and 75% of FVC and showed gravitational dependence after exercise challenge. Conclusion A paradigm testing the response of ventilation to montelukast revealed both a whole‐lung and regional response to exercise challenge and therapy in EIB subjects. J. Magn. Reson. Imaging 2014;39:1230–1237 . © 2013 Wiley Periodicals, Inc .