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T1 mapping in the rat myocardium at 7 tesla using a modified CINE inversion recovery sequence
Author(s) -
Smit Henk,
Guridi Ruben Pellicer,
Guenoun Jamal,
Poot Dirk H. J.,
Doeswijk Gabriela N.,
Milanesi Matteo,
Bernsen Monique R.,
Krestin Gabriel P.,
Klein Stefan,
Kotek Gyula
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24251
Subject(s) - reproducibility , imaging phantom , biomedical engineering , coefficient of variation , nuclear medicine , gadolinium , in vivo , medicine , nuclear magnetic resonance , materials science , chemistry , physics , biology , chromatography , metallurgy , microbiology and biotechnology
Purpose To evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE‐IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla. Materials and Methods The recently published mCINE‐IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations were used to study signal evolution and heart rate dependency. Gadolinium phantoms, a heart specimen and a healthy rat were used to study reproducibility. Two cryo‐infarcted rats were scanned to measure late gadolinium enhancement (LGE). Results In the phantom reproducibility studies the T1 measurements had a maximum coefficient of variation (COV) of 1.3%. For the in vivo reproducibility the COV was below 5% in the anterior cardiac segments. In simulations with phantoms and specimens, a heart rate dependency of approximately 0.5 ms/bpm was present. The T1 maps of the cryo‐infarcted rats showed a clear lowering of T1 in de LGE region. Conclusion The results show that mCINE‐IR is highly reproducible and that the sensitivity allows detecting T1 changes in the rat myocardium. J. Magn. Reson. Imaging 2014;39:901–910. © 2013 Wiley Periodicals, Inc .