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CMR reference values for left ventricular volumes, mass, and ejection fraction using computer‐aided analysis: The Framingham Heart Study
Author(s) -
Chuang Michael L.,
Gona Philimon,
Hautvast Gilion L.T.F.,
Salton Carol J.,
Breeuwer Marcel,
O'Donnell Christopher J.,
Manning Warren J.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24239
Subject(s) - medicine , percentile , ejection fraction , cardiology , framingham heart study , cohort , reference values , offspring , framingham risk score , nuclear medicine , disease , heart failure , mathematics , statistics , pregnancy , biology , genetics
Purpose To determine sex‐specific reference values for left ventricular (LV) volumes, mass, and ejection fraction (EF) in healthy adults using computer‐aided analysis and to examine the effect of age on LV parameters. Materials and Methods We examined data from 1494 members of the Framingham Heart Study Offspring cohort, obtained using short‐axis stack cine SSFP CMR, identified a healthy reference group (without cardiovascular disease, hypertension, or LV wall motion abnormality) and determined sex‐specific upper 95th percentile thresholds for LV volumes and mass, and lower 5th percentile thresholds for EF using computer‐assisted border detection. In secondary analyses, we stratified participants by age‐decade and tested for linear trend across age groups. Results The reference group comprised 685 adults (423F; 61 ± 9 years). Men had greater LV volumes and mass, before and after indexation to common measures of body size (all P = 0.001). Women had greater EF (73 ± 6 versus 71 ± 6%; P = 0.0002). LV volumes decreased with greater age in both sexes, even after indexation. Indexed LV mass did not vary with age. LV EF and concentricity increased with greater age in both sexes. Conclusion We present CMR‐derived LV reference values. There are significant age and sex differences in LV volumes, EF, and geometry, whereas mass differs between sexes but not age groups. J. Magn. Reson. Imaging 2014;39:895–900. © 2013 Wiley Periodicals, Inc .