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Split dynamic MRI: Single bolus high spatial–temporal resolution and multi contrast evaluation of breast lesions
Author(s) -
Grøvik Endre,
Bjørnerud Atle,
Storås Tryggve H.,
Gjesdal KjellInge
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24206
Subject(s) - dynamic contrast enhanced mri , temporal resolution , image resolution , computer science , dynamic contrast , dynamic imaging , breast mri , contrast (vision) , sampling (signal processing) , nuclear medicine , artificial intelligence , magnetic resonance imaging , computer vision , radiology , image processing , physics , medicine , filter (signal processing) , quantum mechanics , digital image processing , image (mathematics) , cancer , breast cancer , mammography
Purpose To test the feasibility of a novel “split dynamic” method in which high temporal and high spatial resolution dynamic MR images are acquired during a single bolus injection. Materials and Methods High temporal resolution images were acquired using a three‐dimensional (3D) dual‐echo EPI sequence. The high spatial resolution images were acquired using a 3D T 1 ‐weighted turbo field echo sequence. Simulations were performed to test the split dynamic method in terms of accuracy relative to a continuous acquisition and for temporal sampling requirements for accurate estimation of kinetic parameters. The method was tested in four patients where pharmacokinetic parameters were extracted from the high temporal resolution data. Results The split dynamic method enabled quantitative evaluation of both T 1 ‐ and T 2 * ‐weighted characteristics. Simulations showed that splitting the dynamic acquisition does not significantly influence the reliability of parameter estimations. Simulation showed a required temporal resolution of 13, 16, and 8 s for accurate estimates of K trans , v e , and v p , respectively, and an optimal sampling interval between 2 and 6 s for peak R 2 * . Conclusion The split dynamic sequence enabled detailed assessment of dynamic T 1 ‐ and T 2 * ‐weighted contrast kinetics without compromising guidelines concerning spatial resolution. J. Magn. Reson. Imaging 2014;39:673–682 . © 2013 Wiley Periodicals, Inc.