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Intravoxel incoherent motion (IVIM) MR imaging of colorectal liver metastases: Are we only looking at tumor necrosis?
Author(s) -
Chiaradia Melanie,
Baranes Laurence,
Nhieu Jeanne Tran,
Vignaud Alexandre,
Laurent Alexis,
Decaens Thomas,
CharlesNelson Anaïs,
Brugières Pierre,
Katsahian Sandrine,
Djabbari Marjane,
Deux JeanFrançois,
Sobhani Iradj,
Karoui Mehdi,
Rahmouni Alain,
Luciani Alain
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24172
Subject(s) - intravoxel incoherent motion , medicine , colorectal cancer , effective diffusion coefficient , necrosis , nuclear medicine , metastasis , magnetic resonance imaging , diffusion mri , perfusion , radiology , pathology , cancer
Purpose To determine if intra‐voxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) parameters, including free molecular‐based (D) and perfusion‐related (D*, f) diffusion parameters, correlate with the degree of tumor necrosis and viable tumor in colo‐rectal cancer (CRC) metastasis. Materials and Methods Fifteen patients referred for resection of liver metastases from CRC were retrospectively included in this Institutional Review Board approved study. An IVIM‐DWI sequence was performed on a 1.5 Tesla MR imaging system, with 10 b factors (0, 10, 20, 30, 50, 80, 100, 200, 400 and 800 s/mm 2 ). Mean D, D*, f and apparent diffusion coefficient (ADC) values were determined in metastases with a longest diameter above 10 mm. Correlations between the diffusion parameters and the degree of liver tumor necrosis and viable tissue were determined (Spearman). Results Correlation between diffusion parameters and histopathological findings was performed in 35 hepatic metastases with a diameter of more than 10 mm (mean size of 17.9 mm; range, 1–68 mm). Both D (r = 0.36; P = 0.035) and ADC (r = 0.4; P = 0.02) correlated with the degree of tumor necrosis but not with viable tumor. Conclusion ADC variation observed in CRC metastases following systemic chemotherapy reflects a specific increase in free‐molecular diffusion (D), in itself correlated to the degree of metastasis necrosis. J. Magn. Reson. Imaging 2014;39:317–325 . © 2013 Wiley Periodicals, Inc .