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Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte‐phase image is a risk factor for hypervascular hepatocellular carcinoma
Author(s) -
Ichikawa Shintaro,
Ichikawa Tomoaki,
Motosugi Utaroh,
Sano Katsuhiro,
Morisaka Hiroyuki,
Enomoto Nobuyuki,
Matsuda Masanori,
Fujii Hideki,
Araki Tsutomu
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24164
Subject(s) - hepatocellular carcinoma , medicine , magnetic resonance imaging , gadoxetic acid , odds ratio , gastroenterology , chronic liver disease , risk factor , prothrombin time , nodule (geology) , albumin , radiology , nuclear medicine , cirrhosis , gadolinium dtpa , biology , paleontology
Purpose To determine whether the presence of a hypovascular nodule in the liver showing hypointensity on hepatocyte‐phase of gadoxetic acid‐enhanced magnetic resonance imaging (EOB‐MRI) is a risk factor for hypervascular hepatocellular carcinoma (HCC) in patients with chronic liver disease. Materials and Methods Forty‐one patients with pathologically confirmed hypervascular HCC and 41 age‐ and gender‐matched controls were retrospectively selected. These patients had undergone EOB‐MRI at least twice: the latest EOB‐MRI and EOB‐MRI performed more than 6 months earlier. History of hypervascular HCC, presence of a hypointense hypovascular nodule in previous hepatocyte‐phase MR images, percent prothrombin time, platelet count, serum levels of albumin, total bilirubin, aspartate aminotransferase, alanine aminotransferase, α‐fetoprotein, and protein induced by vitamin K absence‐II (PIVKA‐II) were variables evaluated by multivariate logistic regression analysis. Results Multivariate analysis revealed that serum albumin level (odds ratio [95% confidence interval], 0.19 [0.06–0.57]; P = 0.0024), history of hypervascular HCC (8.62 [2.71–32.8]; P = 0.0001), and presence of a hypointense hypovascular nodule (4.18 [1.18–17.2]; P = 0.0256) were significant risk factors for hypervascular HCC. Conclusion Patients with chronic liver disease showing a hypointense hypovascular nodule in the liver on hepatocyte‐phase EOB‐MRI have a high risk of HCC development. J. Magn. Reson. Imaging 2014;39:293–297 . © 2013 Wiley Periodicals, Inc .