Premium
Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer
Author(s) -
Kobayashi Shuichiro,
Koga Fumitaka,
Kajino Kohei,
Yoshita Soichiro,
Ishii Chikako,
Tanaka Hiroshi,
Saito Kazutaka,
Masuda Hitoshi,
Fujii Yasuhisa,
Yamada Tetsuo,
Kihara Kazunori
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24148
Subject(s) - effective diffusion coefficient , bladder cancer , ki 67 , medicine , stage (stratigraphy) , diffusion mri , biomarker , imaging biomarker , cancer , nuclear medicine , pathology , magnetic resonance imaging , urology , radiology , chemistry , immunohistochemistry , biology , paleontology , biochemistry
Purpose To elucidate a role of apparent diffusion coefficient (ADC) value as a biomarker of bladder cancer, we investigated its associations with Ki‐67 labeling index (LI) along with classical clinicopathological prognosticators. Materials and Methods Diffusion‐weighted MRI (DW‐MRI) at 1.5 Tesla using b ‐values of 0, 500, 1000, and 2000 s/mm 2 was prospectively taken before transurethral resection by 132 bladder cancer patients. ADC value of index tumors was measured and compared with clinicopathological prognosticators including Ki‐67 LI. Results ADC value was significantly lower in tumors with higher Ki‐67 LIs, sessile tumors (versus papillary), larger tumors, higher grade disease, and higher T stage disease. ADC value inversely correlated with Ki‐67 LI (ρ = −0.57; P < 0.0001). On multiple regression analysis, T stage and Ki‐67 LI significantly correlated with ADC value. The Akaike information criterion confirms these two parameters constitute the best model for determining ADC value. Similarly, T stage and ADC value significantly correlated with Ki‐67 LI and these two parameters composed the best model for predicting Ki‐67 LI. Conclusion ADC value would reflect T stage and Ki‐67 LI, representing invasive and proliferative potential, respectively. ADC value is likely to serve as a biomarker reflecting aggressiveness of bladder cancer. J. Magn. Reson. Imaging 2014;39:172–178. © 2013 Wiley Periodicals, Inc.