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Database of normal japanese gray matter volumes in the default mode network
Author(s) -
Goto Masami,
Abe Osamu,
Aoki Shigeki,
Takao Hidemasa,
Hayashi Naoto,
Miyati Tosiaki,
Mori Harushi,
Kunimatsu Akira,
Ino Kenji,
Yano Keiichi,
Ohtomo Kuni
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24139
Subject(s) - region of interest , default mode network , precuneus , statistical parametric mapping , magnetic resonance imaging , nuclear medicine , medicine , functional magnetic resonance imaging , radiology
Purpose To show the gray matter volumes in the default mode network (DMN) using the atlas‐based method and to evaluate age‐related volume change in the DMN region. Estimation of gray matter volumes is interesting research because previous reports showed an association with gray matter volume (GMV) and diseases. Materials and Methods We focused on five nodes of the DMN (posterior cingulate, precuneus, lateral temporal cortex [LTC], medial prefrontal cortex, and inferior parietal lobule). In all, 1122 healthy adults were included in the present study. T1‐weighted magnetic resonance (MR) images were obtained using a 3T‐MR scanner. To investigate GMV in the DMN, segmented gray matter images were measured by the atlas‐based method, using Statistical Parametric Mapping 5. Volumes were expressed using three different methods: region of interest (ROI)‐volume (mL), the volume itself; ROI‐TIV (%), as a percentage of total intracranial volume (individual difference of head size is corrected); and ROI‐GMV (%), as a percentage of gray matter volume (individual difference of atrophy speed for aging is corrected). Results Negative correlations between measurement values on ROI and age were observed in all five ROIs of the DMN region by two measures of volume (ROI‐volume (mL) and ROI‐TIV (%)), in both genders. In contrast, positive correlations between measurement values on ROI and age were observed in the posterior cingulate and LTC with ROI‐GMV (%), in both genders. Conclusion The present study is the first report about volume change in the DMN that includes age‐related effects. J. Magn. Reson. Imaging 2014;39:132–142. © 2013 Wiley Periodicals, Inc.