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Evaluation of nonscarred myocardial T1 value using contrast‐enhanced look‐locker cardiac MRI and its relationship to cardiac function in dilated cardiomyopathy: Comparison of 1.5 and 3.0 Tesla MRI
Author(s) -
Tachi Masaki,
Amano Yasuo,
Kobayashi Yasuhiro,
Mizuno Kyoichi,
Kumita Shinichiro
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24131
Subject(s) - ejection fraction , medicine , cardiology , magnetic resonance imaging , cardiac function curve , dilated cardiomyopathy , natriuretic peptide , cardiomyopathy , brain natriuretic peptide , cardiac magnetic resonance imaging , heart failure , nuclear medicine , radiology
Purpose To assess relationship between nonscarred myocardial T1 value measured using contrast‐enhanced Look‐Locker MRI and cardiac function in dilated cardiomyopathy (DCM) at 1.5 Tesla (T) and 3.0T MRI. Materials and Methods Contrast‐enhanced Look‐Locker MRI was performed in 35 DCM patients. Nonscarred myocardial and blood T1 values were calculated from the signal intensity values and the delay time obtained on Look‐Locker MRI. We assessed the correlation between the myocardial T1 value or myocardial T1 minus blood T1 value and cardiac function estimated using cine MRI (e.g., end‐diastolic volume: EDV, left ventricular ejection fraction: LVEF) or brain natriuretic peptide (BNP). Results With 1.5T MRI (n = 16), the myocardial T1 value correlated negatively with the EDV(r = −0.66) and end‐systolic volume (ESV; r = −0.68), and positively with the LVEF (r = 0.51); the myocardial T1 minus blood T1 value correlated inversely with EDV (r = −0.70), ESV (r = −0.62), and brain natriuretic peptide (BNP; r = −0.56). With 3.0T MRI (n = 17), the myocardial T1 value correlated negatively with ESV (r = −0.44), septal thickness (r = −0.60), and BNP (r = −0.51), and positively with LVEF (r = 0.61); the myocardial T1 minus blood T1 value negatively correlated with BNP (r = −0.50) and positively with LVEF (r = 0.54). Conclusion The nonscarred myocardial T1 value measured with either 1.5T or 3.0T contrast‐enhanced Look‐Locker MRI is significantly related to cardiac dysfunction in DCM. J. Magn. Reson. Imaging 2013;38:1395–1401. © 2013 Wiley Periodicals, Inc.