Premium
Late gadolinium enhancement in the assessment of the infarcted mouse heart: A longitudinal comparison with manganese‐enhanced MRI
Author(s) -
Skårdal Kristine,
Rolim Natale P.L.,
Haraldseth Olav,
Goa Pål Erik,
Thuen Marte
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24127
Subject(s) - medicine , magnetic resonance imaging , myocardial infarction , histology , stage (stratigraphy) , cardiology , gadolinium , infarction , nuclear medicine , radiology , paleontology , materials science , biology , metallurgy
Purpose To evaluate late gadolinium‐enhanced (LGE) assessment of infarct size, a comparison with manganese‐enhanced magnetic resonance imaging (MEMRI), and histology was performed in a permanent infarction model in the mouse at the acute and chronic stage. Materials and Methods In a paired fashion at the acute and chronic stage after infarction (3–4 days and 21 days, respectively), LGE and MEMRI was performed using a self‐gated fast low flip angle shot (FLASH). Infarct size was evaluated as the enhanced area relative to the complete myocardial wall area in a mid‐ventricular slice. Paired comparisons were made between contrast agents and between timepoints, as well as to histology. Results At the acute stage, LGE delineated a larger infarct size as compared to both MEMRI and histology. Infarct size from LGE decreased from the acute to chronic stage, a temporal development not seen with MEMRI. At the chronic stage, no significant differences in infarct size were found between the methods. Conclusion This study indicates an overenhancement of infarct size when using LGE, supported by an initial overestimation at the acute stage and a temporal decrease in infarct size from the acute to chronic stage, as compared to infarct size from MEMRI. J. Magn. Reson. Imaging 2013;38:1388–1394. © 2013 Wiley Periodicals, Inc.