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Magnetic resonance elastography of liver in healthy asians: Normal liver stiffness quantification and reproducibility assessment
Author(s) -
Venkatesh Sudhakar K.,
Wang Gang,
Teo Lynette L.S.,
Ang Bertrand W.L.
Publication year - 2014
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24084
Subject(s) - intraclass correlation , reproducibility , medicine , magnetic resonance elastography , coefficient of variation , magnetic resonance imaging , elastography , body mass index , confidence interval , transient elastography , stiffness , nuclear medicine , cirrhosis , ultrasound , chemistry , radiology , materials science , liver fibrosis , chromatography , composite material
Purpose To determine normal liver stiffness values evaluated with magnetic resonance elastography (MRE) in healthy normal Asian volunteers and assess its reproducibility. Materials and Methods Liver stiffness was evaluated with MRE in 41 healthy Asians (23 females, 18 males; mean age, 41.8 years, and mean body mass index [BMI], 23.4 kg/m 2 ) on a 1.5T clinical scanner. The correlations between mean liver stiffness and age, gender, BMI, and fat fraction percentage of the liver were studied. Another 12 volunteers underwent liver MRE exams on two separate days 4–6 weeks apart under similar conditions for reproducibility assessment. Intraclass correlation coefficient (ICC) analysis was performed and within‐subject coefficient of variation (CV) of stiffness was estimated. Results The mean ± standard deviation (SD) of liver stiffness in normal healthy Asian subjects was 2.09 ± 0.22 kPa (95% confidence interval [CI], 2.04–2.15 kPa; range 1.68–2.48 kPa). The mean liver stiffness did not significantly correlate with age, gender, BMI, or fat content of the liver. The ICC for mean liver stiffness was 0.90 (95% CI, 0.78–0.96) and CV ranged from 2.2%–11.4%. Conclusion The liver stiffness in normal Asians is not affected by age, gender, BMI, or fat content. Liver stiffness with MRE is highly reproducible. J. Magn. Reson. Imaging 2014;39:1–8. © 2013 Wiley Periodicals, Inc.