Premium
Quantitative 23 Na MRI of human knee cartilage using dual‐tuned 1 H/ 23 Na transceiver array radiofrequency coil at 7 tesla
Author(s) -
Moon Chan Hong,
Kim JungHwan,
Zhao Tiejun,
Bae Kyongtae Ty
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24030
Subject(s) - knee cartilage , radiofrequency coil , cartilage , electromagnetic coil , magnetic resonance imaging , nuclear magnetic resonance , materials science , transceiver , image resolution , nuclear medicine , articular cartilage , biomedical engineering , physics , osteoarthritis , optics , medicine , anatomy , radiology , optoelectronics , alternative medicine , pathology , quantum mechanics , cmos
Purpose To develop quantitative dual‐tuned (DT) 1 H/ 23 Na MRI of human knee cartilage in vivo at 7 Tesla (T). Materials and Methods A sensitive 23 Na transceiver array RF coil was developed at 7T. B 1 fields generated by the transceiver array coil were characterized and corrected in the 23 Na images. Point spread function (PSF) of the 23 Na images was measured, and the signal decrease due to partial‐volume‐effect was compensated in [ 23 Na] quantification of knee cartilage. SNR and [ 23 Na] in anterior femoral cartilage were measured from seven healthy subjects. Results SNR of 23 Na image with the transceiver array coil was higher than that of birdcage coil. SNR in the cartilage at 2‐mm isotropic resolution was 26.80 ± 3.69 (n = 7). B 1 transmission and reception fields produced by the DT coil at 7T were similar to each other. Effective full‐width‐half‐maximum of 23 Na image was ∼5 mm at 2‐mm resolution. Mean [ 23 Na] was 288.13 ± 29.50 mM (n = 7) in the anterior femoral cartilage of normal subjects. Conclusion We developed a new high‐sensitivity 23 Na RF coil for knee MRI at 7T. Our 1 H/ 23 Na MRI allowed quantitative measurement of [ 23 Na] in knee cartilage by measuring PSF and cartilage thickness from 23 Na and 1 H image, respectively. J. Magn. Reson. Imaging 2013;38:1063–1072. © 2013 Wiley Periodicals, Inc.