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Simultaneous magnetic resonance angiography and perfusion (MRAP) measurement: Initial application in lower extremity skeletal muscle
Author(s) -
Wright Katherine L.,
Seiberlich Nicole,
Jesberger John A.,
Nakamoto Dean A.,
Muzic Raymond F.,
Griswold Mark A.,
Gulani Vikas
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24020
Subject(s) - magnetic resonance angiography , perfusion , medicine , magnetic resonance imaging , contrast (vision) , repeatability , angiography , nuclear medicine , sampling (signal processing) , nuclear magnetic resonance , radiology , chemistry , physics , chromatography , detector , optics
Purpose To obtain a simultaneous 3D magnetic resonance angiography and perfusion (MRAP) using a single acquisition and to demonstrate MRAP in the lower extremities. A time‐resolved contrast‐enhanced exam was used in MRAP to simultaneously acquire a contrast‐enhanced MR angiography (MRA) and dynamic contrast‐enhanced (DCE) perfusion, which currently requires separate acquisitions and thus two contrast doses. MRAP can be used to assess large and small vessels in vascular pathologies such as peripheral arterial disease. Materials and Methods MRAP was performed on 10 volunteers following unilateral plantar flexion exercise (one leg exercised and one rested) on two separate days. Data were acquired after administration of a single dose of contrast agent using an optimized sampling strategy, parallel imaging, and partial‐Fourier acquisition to obtain a high spatial resolution, 3D‐MRAP frame every 4 seconds. Two radiologists assessed MRAs for image quality, a signal‐to‐noise ratio (SNR) analysis was performed, and pharmacokinetic modeling yielded perfusion ( K trans ). Results MRA images had high SNR and radiologist‐assessed diagnostic quality. Mean K trans ± standard error were 0.136 ± 0.009, 0.146 ± 0.012, and 0.191 ± 0.012 min −1 in the resting tibialis anterior, gastrocnemius, and soleus, respectively, which significantly increased with exercise to 0.291 ± 0.018, 0.270 ± 0.019, and 0.338 ± 0.022 min −1 . Bland–Altman analysis showed good repeatability. Conclusion MRAP provides simultaneous high‐resolution MRA and quantitative DCE exams to assess large and small vessels with a single contrast dose. Application in skeletal muscle shows quantitative, repeatable perfusion measurements, and the ability to measure physiological differences. J. Magn. Reson. Imaging 2013;38:1237–1244. © 2013 Wiley Periodicals, Inc.