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Diffusion tensor imaging of normal‐appearing white matter in unilateral cerebral arterial occlusive disease
Author(s) -
Meng Xiangshui,
Wang Qing,
Hou Jinwen,
Zhang Xiaoming,
Wang Enguo,
Li Qilu,
Zeng Qingshi,
Wang Qian,
Li Chuanfu,
Ma Xiangxing
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.24004
Subject(s) - diffusion mri , corona radiata (embryology) , fractional anisotropy , medicine , white matter , radiata , nuclear medicine , stenosis , effective diffusion coefficient , occlusion , radiology , magnetic resonance imaging , cardiology , agronomy , vigna , ovarian follicle , biology , hormone , cumulus oophorus
Purpose To use MR with diffusion tensor imaging (DTI) and conventional and high b value to assess diffusion changes in normal‐appearing white matter (NAWM) in patients with unilateral, severe stenosis, or occlusion of the middle cerebral artery (MCA). Materials and Methods In total, 28 patients with NAWM and unilateral, severe stenosis, or occlusion of the MCA underwent DTI with b values 1000 and 2200 s/mm 2 at 3.0T MR. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (eigenvalues λ 1 , λ 2 ), and axial diffusivity (eigenvalue λ 3 ) were measured for the ipsilateral and contralateral corona radiata. Results Mean FA was significantly lower for the ipsilateral than contralateral corona radiata with high b value, 2200 s/mm 2 , and ipsilateral corona radiata with conventional low b value, 1000 s/mm 2 (all P < 0.01). Mean ADC, λ 1 , λ 2 , and λ 3 were significantly higher for the ipsilateral than contralateral corona radiata with high b value (all P < 0.05) but not for ipsilateral than contralateral corona radiata with low b value ( P > 0.05). Conclusion DTI with a high b value detects diffusion changes in NAWM in patients with unilateral, severe stenosis, or occlusion of the MCA not seen with conventional b value or conventional MRI contrasts. J. Magn. Reson. Imaging 2013;38:650–654. © 2012 Wiley Periodicals, Inc.