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Combined parallel and partial fourier MR reconstruction for accelerated 8‐channel hyperpolarized carbon‐13 in vivo magnetic resonance Spectroscopic imaging (MRSI)
Author(s) -
Ohliger Michael A.,
Larson Peder E.Z.,
Bok Robert A.,
Shin Peter,
Hu Simon,
Tropp James,
Robb Fraser,
Carvajal Lucas,
Nelson Sarah J.,
Kurhanewicz John,
Vigneron Daniel B.
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23989
Subject(s) - undersampling , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , magnetic resonance imaging , iterative reconstruction , materials science , image resolution , fourier transform , aliasing , voxel , k space , biomedical engineering , optics , physics , computer science , medicine , radiology , artificial intelligence , quantum mechanics
Purpose: To implement and evaluate combined parallel magnetic resonance imaging (MRI) and partial Fourier acquisition and reconstruction for rapid hyperpolarized carbon‐13 ( 13 C) spectroscopic imaging. Short acquisition times mitigate hyperpolarized signal losses that occur due to T1 decay, metabolism, and radiofrequency (RF) saturation. Human applications additionally require rapid imaging to permit breath‐holding and to minimize the effects of physiologic motion. Materials and Methods: Numerical simulations were employed to validate and characterize the reconstruction. In vivo MR spectroscopic images were obtained from a rat following injection of hyperpolarized 13 C pyruvate using an 8‐channel array of carbon‐tuned receive elements. Results: For small spectroscopic matrix sizes, combined parallel imaging and partial Fourier undersampling resulted primarily in decreased spatial resolution, with relatively less visible spatial aliasing. Parallel reconstruction qualitatively restored lost image detail, although some pixel spectra had persistent numerical error. With this technique, a 30 × 10 × 16 matrix of 4800 3D MR spectroscopy imaging voxels from a whole rat with isotropic 8 mm 3 resolution was acquired within 11 seconds. Conclusion: Parallel MRI and partial Fourier acquisitions can provide the shorter imaging times and wider spatial coverage that will be necessary as hyperpolarized 13 C techniques move toward human clinical applications. J. Magn. Reson. Imaging 2013;38:701–713. © 2013 Wiley Periodicals, Inc.