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Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion: In vivo canine model
Author(s) -
Oh Tong In,
Jeong Woo Chul,
McEwan Alistair,
Park Hee Myung,
Kim Hyung Joong,
Kwon Oh In,
Woo Eung Je
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23960
Subject(s) - magnetic resonance imaging , in vivo , lesion , abscess , medicine , pulse (music) , brain abscess , tomography , nuclear magnetic resonance , nuclear medicine , radiology , biomedical engineering , pathology , surgery , optics , physics , microbiology and biotechnology , detector , biology
Purpose To show the feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging in terms of its capability to provide new contrast information of abscess lesion and characterize time‐course variations before and after the induction of brain abscess. Materials and Methods Brain abscess was induced in healthy beagles by a direct inoculation method using Staphylococcus pseudintermedius . After the induction, four electrodes were attached on the head and the dog was placed inside the magnetic resonance imaging (MRI) bore. Using a current source, we injected a current of amplitude 5 mA and a pulse width of 81 msec. A multi‐echo ICNE pulse sequence was used to obtain the magnetic flux density ( B z ) data. Results The relative conductivity contrast ratios (rCCR, %) of abscess lesion were significantly changed by the postinduction time ( P < 0.01). The rCCRs of central abscess lesions were higher than the surrounding area at 6, 12, and 18 hours ( P < 0.01). Over 12 hours, the relationship between the induction time and rCCR showed a positive correlation followed by a negative correlation ( P < 0.01). Conclusion We performed in vivo disease model animal experiments to validate the MREIT technique providing conductivity information of tissues in situ to be utilized in clinical applications. J. Magn. Reson. Imaging 2013;38:189–197. © 2012 Wiley Periodicals, Inc.