Premium
Role of diffusion‐weighted magnetic resonance imaging in the diagnosis of gallbladder cancer
Author(s) -
Kim Soo Jin,
Lee Jeong Min,
Kim Hyungjin,
Yoon Jeong Hee,
Han Joon Koo,
Choi Byung Ihn
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23956
Subject(s) - magnetic resonance imaging , diffusion weighted magnetic resonance imaging , medicine , diffusion mri , gallbladder , radiology , nuclear magnetic resonance , gallbladder cancer , cancer , physics
Purpose To determine the additional diagnostic value of high b‐value diffusion‐weighted imaging (DWI) compared to conventional biliary magnetic resonance imaging (MRI) for differentiating gallbladder (GB) cancer from benign GB diseases with wall thickening. Materials and Methods Thirty‐nine patients with GB cancers and 36 patients with cholecystitis having preoperative biliary MRIs were included. All patients underwent unenhanced T1‐ and T2‐weighted imaging (T2WI), Gd‐enhanced dynamic MRI, and DWI (b values 0, 100, 500, 1000 s/mm 2 ). Two radiologists independently analyzed two sets of MRI for characterization of GB lesions: a conventional biliary image (CBI) set with T1‐ and T2WI and a dynamic image; and a DWI set composed of DWI and a CBI set. Diagnostic accuracy and sensitivity were evaluated using the receiver operator characteristic method. The mean apparent diffusion coefficient (ADC) values of the lesions were also calculated. Results The Az values were 0.856 and 0.960 for reviewers 1 and 2, respectively, with the CBI set and increased to 0.952 and 0.983 with the DWI set. The mean ADC value of GB carcinoma was 1.46 ± 0.45 × 10 −3 mm 2 /s and that of cholecysititis was 2.16 ± 0.56 × 10 −3 mm 2 /s ( P < 0.0001). Conclusion Adding DWI to the standard biliary MRI protocol may improve sensitivity for distinguishing GB cancers from benign GB diseases with wall thickening. J. Magn. Reson. Imaging 2013;38:127–137. © 2012 Wiley Periodicals, Inc.