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Hyperpolarized helium‐3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation
Author(s) -
Kirby Miranda,
Kanhere Nikhil,
EtemadRezai Roya,
McCormack David G.,
Parraga Grace
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23896
Subject(s) - medicine , exacerbation , copd , magnetic resonance imaging , pulmonary disease , nuclear medicine , pulmonary function testing , copd exacerbation , effective diffusion coefficient , radiology , cardiology , acute exacerbation of chronic obstructive pulmonary disease
Abstract A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium‐3 ( 3 He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). About 2.5 years pre‐AE, 3 He ventilation defect percent (VDP) was 16%, the apparent diffusion coefficient (ADC) was 0.34 cm 2 /s, and forced expiratory volume in 1 sec (FEV 1 ) was 41% pred . Six months pre‐AE, VDP and ADC were worse (29% and 0.38 cm 2 /s, respectively) without worsening FEV 1 (47% pred ). After hospitalization and AE treatment, VDP was 20%, whereas FEV 1 did not improve (45% pred ); 16 months post‐AE, both VDP and ADC remained improved and similar to 4 years prior. J. Magn. Reson. Imaging 2013;37:1223–1227. © 2012 Wiley Periodicals, Inc.