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Changes in apparent diffusion coefficient and T 2 relaxation during radiotherapy for prostate cancer
Author(s) -
Foltz Warren D.,
Wu Andy,
Chung Peter,
Catton Charles,
Bayley Andrew,
Milosevic Michael,
Bristow Robert,
Warde Padraig,
Simeonov Anna,
Jaffray David A.,
Haider Masoom A.,
Ménard Cynthia
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23885
Subject(s) - medicine , prostate cancer , effective diffusion coefficient , prostate , nuclear medicine , radiation therapy , repeatability , diffusion mri , prospective cohort study , urology , cancer , radiology , magnetic resonance imaging , chemistry , chromatography
Purpose: To evaluate regional and temporal changes in apparent diffusion coefficient (ADC) and T 2 relaxation during radiation therapy (RT) in patients with low and intermediate risk localized prostate cancer. Materials and Methods: Seventeen patients enrolled on a prospective clinical trial where MRI was acquired every 2 weeks throughout eight weeks of image‐guided prostate IMRT (78 Gy/39 fractions). ADC and T 2 quantification used entire prostate, central gland, benign peripheral zone, and tumor‐dense regions‐of‐interest, and mean values were evaluated for common response trends. Results: Overall, the RT responses were greater than volunteer measurement repeatability, and week 6 appeared to be an optimum time‐point for early detection. RT effects on the entire prostate were best detected using ADC (5–7% by week 2, P < 0.0125), effects on peripheral zone were best detected using T 2 (19% reduction at week 6; P = 0.004) and effects on tumors were best detected using ADC (14% elevation at week 6; P = 0.004). Conclusion: ADC and T 2 may be candidate biomarkers of early response to RT warranting further investigation against clinical outcomes. J. Magn. Reson. Imaging 2013;37:909–916. © 2012 Wiley Periodicals, Inc.