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Ferumoxytol in clinical practice: Implications for MRI
Author(s) -
McCullough Brendan J.,
Kolokythas Orpheus,
Maki Jeffrey H.,
Green Douglas E.
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23879
Subject(s) - ferumoxytol , medicine , magnetic resonance imaging , radiology , nuclear medicine , gadolinium , food and drug administration , environmental health , materials science , metallurgy
Ferumoxytol is an iron‐containing parenteral treatment for iron deficiency anemia that was recently approved by the Food and Drug Administration. The iron is in the form of a superparamagnetic iron oxide that causes T1, T2, and T2* shortening on magnetic resonance imaging (MRI). Furthermore, the drug has a long intravascular half‐life of 14–15 hours; a standard dose can affect MRI for days to months. We describe a case in which a patient underwent contrast‐enhanced MRI of the liver 2 days after receiving a dose of ferumoxytol, which was unknown to the radiology team. The blood pool and soft tissues were hyperintense on T1‐weighted images, concealing enhancement from the gadolinium‐based contrast agent that was administered during the exam and rendering the exam nondiagnostic. Radiologists must be aware of this potential effect in screening patients for MRI and interpreting exams. J. Magn. Reson. Imaging 2013;37:1476–1479. © 2012 Wiley Periodicals, Inc.