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Sampling requirements in DCE‐MRI based analysis of high grade gliomas: Simulations and clinical results
Author(s) -
Larsson Christopher,
Kleppestø Magne,
Rasmussen Inge,
Salo Raimo,
Vardal Jonas,
Brandal Petter,
Bjørnerud Atle
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23866
Subject(s) - truncation (statistics) , statistics , mathematics , nuclear medicine , sampling (signal processing) , physics , medicine , optics , detector
Purpose: To investigate the effect of variations in temporal resolution and total measurement times on the estimations of kinetic parameters derived from dynamic contrast‐enhanced (DCE) MRI in patients with high‐grade gliomas (HGGs). Materials and Methods: DCE‐MRI with high temporal resolution (dynamic sampling time (T s ) = 2.1 s and 3.4 s) and total sampling time (T acq ) of 5.2 min was acquired in 101 examinations from 15 patients. Using the modified Tofts model K trans , k ep v e and v p were estimated. The effects of increasing T s and reducing T acq on the estimated kinetic parameters were estimated through down‐sampling and data truncation, and the results were compared with numerical simulations. Results: There was an overall dependence of all four kinetic parameters on T s and T acq . Increasing T s resulted in under‐estimation of K trans and over‐estimation of V p , whereas k ep and V e varied in a less predictable manner. Reducing T acq resulted in over‐estimation of K trans and k ep and under‐estimation of v p and v e . Increasing T s and reducing T acq resulted in increased relative error for all four parameters. Conclusion: Estimated K trans , K ep , and V e in HGGs were within 15% of the high sampling rate reference values for T s <20 s. Increasing T s and reducing T acq leads to reduced precision of the estimated values. J. Magn. Reson. Imaging 2013;37:818–829. © 2012 Wiley Periodicals, Inc.