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Adipose tissue MRI for quantitative measurement of central obesity
Author(s) -
Poonawalla Aziz H.,
Sjoberg Brett P.,
Rehm Jennifer L.,
Hernando Diego,
Hines Catherine D.,
Irarrazaval Pablo,
Reeder Scott B.
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23846
Subject(s) - adipose tissue , waist , overweight , medicine , magnetic resonance imaging , nuclear medicine , circumference , obesity , radiology , mathematics , geometry
Purpose: To validate adipose tissue magnetic resonance imaging (atMRI) for rapid, quantitative volumetry of visceral adipose tissue (VAT) and total adipose tissue (TAT). Materials and Methods: Data were acquired on normal adults and clinically overweight girls with Institutional Review Board (IRB) approval/parental consent using sagittal 6‐echo 3D‐spoiled gradient‐echo (SPGR) (26‐sec single‐breath‐hold) at 3T. Fat‐fraction images were reconstructed with quantitative corrections, permitting measurement of a physiologically based fat‐fraction threshold in normals to identify adipose tissue, for automated measurement of TAT, and semiautomated measurement of VAT. TAT accuracy was validated using oil phantoms and in vivo TAT/VAT measurements validated with manual segmentation. Group comparisons were performed between normals and overweight girls using TAT, VAT, VAT‐TAT‐ratio (VTR), body‐mass‐index (BMI), waist circumference, and waist‐hip‐ratio (WHR). Results: Oil phantom measurements were highly accurate (<3% error). The measured adipose fat‐fraction threshold was 96% ± 2%. VAT and TAT correlated strongly with manual segmentation (normals r 2 ≥ 0.96, overweight girls r 2 ≥ 0.99). VAT segmentation required 30 ± 11 minutes/subject (14 ± 5 sec/slice) using atMRI, versus 216 ± 73 minutes/subject (99 ± 31 sec/slice) manually. Group discrimination was significant using WHR ( P < 0.001) and VTR ( P = 0.004). Conclusion: The atMRI technique permits rapid, accurate measurements of TAT, VAT, and VTR. J. Magn. Reson. Imaging 2013;37:707–716. © 2012 Wiley Periodicals, Inc.