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White matter changes in primary dystonia determined by 2D distribution analysis of diffusion tensor images
Author(s) -
Vo An,
Eidelberg David,
Uluǧ Aziz M.
Publication year - 2013
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23805
Subject(s) - diffusion mri , fractional anisotropy , white matter , dystonia , voxel , medicine , nuclear medicine , nuclear magnetic resonance , neuroscience , pathology , magnetic resonance imaging , radiology , physics , psychology , psychiatry
Purpose: To determine brain tissue affected by dystonia by making group comparison of parameter‐based diffusion tensor imaging (DTI) distributions of patients with control subjects. A 2D distribution analysis of mean diffusivity and fractional anisotropy index was used for modeling brain tissues according to the inherent diffusion characteristics. Materials and Methods: Seven affected carriers of the DYT1 dystonia mutation and eight healthy control subjects were imaged for a previous study. We employed a 2D distribution analysis of all the diffusion voxels and a four compartmental brain model for group comparison of the dystonia subjects and controls. Results: Our analysis showed disease involvement in the white matter of the patients. Excellent tissue characterization was achieved automatically using the 2D distribution analysis based on a physical brain model. Conclusion: This 2D analysis implicated white matter in dystonia and could be useful as a screening tool in diseases with unknown pathologies. J. Magn. Reson. Imaging 2013;37:59–66. © 2012 Wiley Periodicals, Inc.