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Assessment of the liver strain among cirrhotic and normal livers using tagged MRI
Author(s) -
Mannelli Lorenzo,
Wilson Gregory J.,
Dubinsky Theodore J.,
Potter Christopher A.,
Bhargava Puneet,
Cuevas Carlos,
Linnau Ken F.,
Kolokythas Orpheus,
Gunn Martin L.,
Maki Jeffrey H.
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23743
Subject(s) - cirrhosis , medicine , magnetic resonance imaging , strain (injury) , liver disease , chronic liver disease , nuclear medicine , radiology
Purpose: To use magnetization tagged magnetic resonance imaging (MRI) (tag‐MRI) to quantify cardiac induced liver strain and compare strain of cirrhotic and normal livers. Materials and Methods: Tag‐MRI was performed at 1.5T on eight subjects with no history of liver disease and 10 patients with liver cirrhosis. A breath‐hold peripheral pulse‐gated (PPG) conventional tag‐MRI cine sequence was performed with planes to include the left lobe of the liver and the inferior wall of the heart. Commercially available software HARP (Diagnosoft, Palo Alto, CA) was used for image analysis and strain calculation. Three regions‐of‐interest (ROIs) were selected: segment II of the liver near the heart (A), right liver lobe far from the heart (B), and the left ventricular wall (C). The average and maximal (max) strain were measured in A, B, and C. The maximum strains were used to generate a cardiac‐corrected strain gradient: (maxA‐maxB)/maxC. Results were compared with Student's t ‐test (SPSS, Chicago, IL). Results: In subjects with no history of liver disease vs. cirrhotic patients, the average strain was 22% ± 7% vs. 4% ± 3% ( P < 0.001), the max strain was 63% ± 15% vs. 17% ± 5% ( P < 0.001), and the corrected strain gradient was 0.52 ± 0.16 vs. 0.11% ± 0.08%. Conclusion: There is a significant difference in liver strain measured with tag‐MRI between subjects with no history of liver disease and patients with cirrhosis. J. Magn. Reson. Imaging 2012; 36:1490–1495. © 2012 Wiley Periodicals, Inc.