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Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: Early experience
Author(s) -
Milot Laurent,
Haider Masoom,
Foster Lynette,
McGregor Cailtin,
Law Calvin
Publication year - 2012
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/jmri.23650
Subject(s) - medicine , focal nodular hyperplasia , magnetic resonance imaging , hemangioma , radiology , hepatocellular carcinoma , nuclear medicine , cyst
Purpose: To investigate enhancement of hepatic lesions with gadofosveset trisodium (Gdfos) (Ablavar) (blood pool agent) compared with the extracellular gadolinium contrast agent (EcGd) gadobutrol (Gadovist). Materials and Methods: The prospective study was approved by the Institutional Research Ethics Board with informed consent. Twelve patients underwent magnetic resonance imaging (MRI) with EcGd followed by MRI with Gdfos. For each agent qualitative analysis described the pattern of enhancement and quantitative analysis was performed using lesion‐to‐liver contrast‐to‐noise (CNR) ratio. Paired and unpaired Student's t ‐test used. Results: Twelve hemangiomas, four metastases, one cyst, two focal nodular hyperplasia (FNH), and three adenomas were found. Cyst, FNH, adenomas, and hemangiomas demonstrated the classic pattern of enhancement with both agents. Hemangiomas demonstrated retention of contrast with both agents and their CNR was not statistically different ( P > 0.05). Metastases demonstrated retention of contrast on delayed phase with EcGd. Retention of contrast was not seen in metastases with Gdfos. CNR of metastases with Gdfos was statistically lower than CNR of metastases with EcGd ( P = 0.005). CNR of hemangiomata and metastases on delayed phase were significantly different ( P = 0.0008) with Gdfos, but similar with EcGd ( P = 0.4). Conclusion: Hemangiomas accumulate Gdfos on delayed phase and metastases do not, a key additional differentiating feature. Liver imaging with Gdfos may improve characterization of liver lesions. J. Magn. Reson. Imaging 2012;36:738–742. © 2012 Wiley Periodicals, Inc.